This computer wasn't 100% MS-DOS compatible, but is intended to work under EOS 16.
EOS 16 is an operating system, which looks like UNIX and is fully compatible with Concurrent CP/M and CP/M 86 and can execute programs for MS-DOS 1.4 or MS-DOS 2.0.
Sharp developed a Z80 card for the MZ 5600, with this card, EOS 16 can execute programs written for EOS V3 (EOS for 8 bit systems) or CP/M 80.
The EOS 16 shell is very powerful and uses UNIX features.
The MZ 5600 supports several disk formats: 640 KB (when it is used with MSDOS), 800 KB (to use programs written for the MZ 3541) or 320 KB (old MS-DOS format).